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Appendix A — Experimental Test Protocols
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Appendix A — Experimental Test Protocols

Open Science & License: This protocol is released under Creative Commons CC BY-SA 4.0. You may copy, adapt, and build upon it—even commercially—provided you give appropriate credit and share derivatives under the same license. Pre-register deviations and report all results (including null) for transparency.

The Fructose Model: Bibliography
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The Fructose Model: Bibliography

The Fructose Model – Master Bibliography How to read this bibliography: Throughout our white papers we cite short tags (e.g., [CORE-RSTB2023]). Each tag links here for the full citation and a one-line purpose note. This page is a living, project-wide...

Whitepaper Series: The Fructose Model — The Metabolic Energy Failure Framework
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Whitepaper Series: The Fructose Model — The Metabolic Energy Failure Framework

Executive Summary Thesis: Across chronic disease, a recurring early signature appears: cellular energy failure. Many stressors can cause it — infection, toxins, hypoxia, inflammation — but the most universal and modifiable amplifier is fructose metabolism, specifically phosphorylation by fructokinase (KHK)...

7.0 Intervention Strategies: Turning Down the Survival Switch
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7.0 Intervention Strategies: Turning Down the Survival Switch

Abstract Most public health strategies against metabolic disease have focused on restriction — eat less, avoid sugar, exercise more. Yet despite decades of effort, obesity, diabetes, fatty liver, and hypertension have surged worldwide. The Fructose Model offers a new explanation:...

6.4 Cancer: Fragile Cells, Fertile Ground
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6.4 Cancer: Fragile Cells, Fertile Ground

Abstract Cancer is often described in terms of mutations, oncogenes, and signaling pathways. But beneath this genetic complexity lies a simpler, universal feature: a disrupted energy state. Cancer cells thrive in low-oxygen, glycolytic conditions — the so-called Warburg effect [CANC-W1956a]....

6.3 Neurodegeneration: The Brain on Fragile Energy
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6.3 Neurodegeneration: The Brain on Fragile Energy

Abstract The brain is the most energy-demanding organ in the body, consuming about 20% of total resting energy while representing only 2% of body mass. This dependence makes neurons uniquely vulnerable to metabolic disruptions. Dietary fructose itself barely crosses the...

6.2 Cardiovascular Disease: Fragile Vessels from Fragile Energy
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6.2 Cardiovascular Disease: Fragile Vessels from Fragile Energy

Abstract Cardiovascular disease (CVD) remains the leading global cause of death. Traditional risk factors — salt, obesity, and cholesterol — have been treated as independent variables, but all converge on a deeper upstream mechanism: fructose metabolism. Fructose rapidly consumes ATP,...

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