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6.1 Metabolic Dysfunction: The Primary Fingerprint of the Fructose Pathway

6.1 Metabolic Dysfunction: The Primary Fingerprint of the Fructose Pathway

Obesity, type 2 diabetes, fatty liver disease, gout, and chronic kidney disease (CKD) are not separate epidemics — they are the most direct outputs of chronic fructose metabolism.

5.3 Fructose Historical Context: From Scarcity to Excess

5.3 Fructose Historical Context: From Scarcity to Excess

Abstract For most of human history, fructose exposure was rare, seasonal, and tightly bound to survival. Honey, ripe fruit, and alcohol were the only meaningful sources, and their availability was limited. Fructose metabolism served its purpose well: to store fat,...

5.2 The Fruit Paradox: How Nature Balances Fructose

5.2 The Fruit Paradox: How Nature Balances Fructose

Abstract Fruit is not “good” or “bad.” It is a complex food whose balance shifts as it ripens — and even while it sits on the counter. In the wild, fruit demonstrates the logic of the fructose survival pathway: bitterness...

5.1 Lessons from Nature: Fructose as a Survival Tool

5.1 Lessons from Nature: Fructose as a Survival Tool

Abstract Fructose metabolism is not a mistake. It is one of nature’s most reliable survival programs, appearing across species and environments whenever water, oxygen, or food are scarce [NAT-J2020]. Bears use it to fatten for hibernation [NAT-B2002]. Birds stretch their...

4.0 Fat Gain as a Natural Consequence

4.0 Fat Gain as a Natural Consequence

Abstract Fructose metabolism is not a mistake — it is a program for energy management. In times of abundance, it promotes fat storage; in times of scarcity, it conserves energy by lowering metabolism [CORE-RSTB2023]. This dual function explains why fat...

3.0 Endogenous Fructose Production

3.0 Endogenous Fructose Production

Abstract Fructose is not only something we eat — the body can also make its own fructose through the polyol pathway [ENDO-L2013]. In response to stressors such as high glucose, salt, dehydration, alcohol, or low oxygen, glucose is converted into...

2.0 Fragile Cells → Fragile Systems

2.0 Fragile Cells → Fragile Systems

Abstract Chronic diseases don’t begin at the organ level — they begin at the cellular level. When cells lose the ability to sustain stable energy production, they become fragile. A few fragile cells can be tolerated, but as they accumulate,...

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